Publications sur la Protonthérapie par l’équipe médicale de SAH

 

Allan F. Thornton, MD
MICRODOSIMETRIC MEASUREMENTS FOR NEUTRON-ABSORBED DOSE DETERMINATION DURING PROTON THERAPY.Pérez-Andújar, A., Deluca, P. M., Thornton, A. F., Fitzek, M., Hecksel, D., Farr, J.; Radiat Prot Dosimetry. 2012 Aug.
Validation of dosimetric field matching accuracy from proton therapy using a robotic patient positioning system.Farr, J.B., O'Ryan-Blair, A., Jesseph, F., Hsi, W., Allgower, C.E., Mascia, A.E., Thornton, A.F., Schreuder, A.N.; J Appl Clin Med Phys. 2010.
Hyperacute neuropathological findings after proton beam radiosurgery of the rat hippocampus.Brisman, J.L., Cosgrove, G.R., Thornton, A.F., Beer, T., Bradley-Moore, M., Shay, C.T., Hedley-Whyte, E.T., Cole, A.J.; Neurosurgery. 2005 Jun.
The dentist's role in an emerging cancer treatment technology.Smith, M.S., Thornton, A.F.; J Indiana Dent Assoc. 2005.
Radiosurgery of the rat hippocampus: magnetic resonance imaging, neurophysiological, histological, and behavioral studies.Brisman, J.L., Cole, A.J., Cosgrove, G.R., Thornton, A.F., Rabinov, J., Bussiere, M., Bradley-Moore, M., Hedley-Whyte, T., Chapman, P.H.; Neurosurgery. 2003 Oct.
In vivo 3-T MR spectroscopy in the distinction of recurrent glioma versus radiation effects: initial experience.Rabinov, J.D., Lee, P.L., Barker, F.G., Louis, D.N., Harsh, G.R., Cosgrove, G.R., Chiocca, E.A., Thornton, A.F., Loeffler, J.S., Henson, J.W., Gonzalez, R.G.; Radiology. 2002 Dec.
Proton beam stereotactic radiosurgery of vestibular schwannomas.Harsh, G.R., Thornton, A.F., Chapman, P.H., Bussiere, M.R., Rabinov, J.D., Loeffler, J.S.; Int J Radiat Oncol Biol Phys. 2002 Sep 1.
Neuroendocrine tumors of the sinonasal tract. Results of a prospective study incorporating chemotherapy, surgery, and combined proton-photon radiotherapy.Fitzek, M.M., Thornton, A.F., Varvares, M., Ancukiewicz, M., Mcintyre, J., Adams, J., Rosenthal, S., Joseph, M., Amrein, P.; Cancer. 2002 May 15.
Neoadjuvant therapy for organ preservation in head and neck cancer.Urba, S. G., Wolf, G. T., Bradford, C. R., Thornton, A. F., Eisbruch, A., Terrell, J. E., Carpenter, V., Miller, T., Tang, G., Strawderman, M.; Laryngoscope. 2000 Dec.
Malignant astrocytomas: focal tumor recurrence after focal external beam radiation therapy.Liang, B. C., Thornton, A. F., Sandler, H. M., Greenberg, H. S.; J Neurosurg. 1991 Oct.
Radiation-induced optic neuropathy: correlation of MR imaging and radiation dosimetry.Young, W. C., Thornton, A. F., Gebarski, S. S., Cornblath, W. T.; Radiology. 1992 Dec.
Automated determination of patient setup errors in radiation therapy using spherical radio-opaque markers.Lam, K. L., Ten Haken, R. K., McShan, D. L., Thornton, A. F.; Med Phys. 1993 Jul 01.
Technical advances in radiotherapy of head and neck tumors.Thornton, A. F., Laramore, G. E.; Hematol Oncol Clin North Am. 1999 Aug.
Intensive induction chemotherapy and radiation for organ preservation in patients with advanced resectable head and neck carcinoma.Urba, S. G., Forastiere, A. A., Wolf, G. T., Esclamado, R. M., McLaughlin, P. W., Thornton, A. F.; J Clin Oncol. 1994 May.
Olfactory neuroblastoma: the results of modern treatment approaches at the University of Michigan.Zappia, J. J., Carroll, W. R., Wolf, G. T., Thornton, A. F., Ho, L., Krause, C. J.; Head Neck. 1993 May 01.
A head immobilization system for radiation simulation, CT, MRI, and PET imaging.Thornton, A. F., Ten Haken, R. K., Weeks, K. J., Gerhardsson, A., Correll, M., Lash, K. A.; Med Dosim. 1991 Jun.
Three-dimensional treatment planning of astrocytomas: a dosimetric study of cerebral irradiation.Thornton, A. F., Hegarty, T. J., Ten Haken, R. K., Yanke, B. R., LaVigne, M. L., Fraass, B. A., McShan, D. L., Greenberg, H. S.; Int J Radiat Oncol Biol Phys. 1991 Jun.
A quantitative assessment of the addition of MRI to CT-based, 3-D treatment planning of brain tumors.Ten Haken, R. K., Thornton, A. F., Sandler, H. M., LaVigne, M. L., Quint, D. J., Fraass, B. A., Kessler, M. L., McShan, D. L.; Radiother Oncol. 1992 Oct.
Three-dimensional motion analysis of an improved head immobilization system for simulation, CT, MRI, and PET imaging.Thornton, A. F., Ten Haken, R. K., Gerhardsson, A., Correll, M.; Radiother Oncol. 1991 Apr.
Chemotherapy followed by accelerated fractionated radiation for larynx preservation in patients with advanced laryngeal cancer.Eisbruch, A., Thornton, A. F., Urba, S., Esclamado, R. M., Carroll, W. R., Bradford, C. R., Hazuka, M. B., Littles, F. J., Strawderman, M., Wolf, G. T.; J Clin Oncol. 1996 Aug.
Recommendations for treatment of brain metastases.Thornton, A. F., Harsh, G. R.; Neurosurg Clin N Am. 1996 Jul.
Results of re-irradiation of primary intracranial neoplasms with three-dimensional conformal therapy.Kim, H. K., Thornton, A. F., Greenberg, H. S., Page, M. A., Junck, L., Sandler, H. M.; Am J Clin Oncol. 1997 Aug.
Spinal cord astrocytomas: results of therapy.Sandler, H. M., Papadopoulos, S. M., Thornton, A. F., Ross, D. A.; Neurosurgery. 1992 Apr.
Intra-arterial bromodeoxyuridine radiosensitization of malignant gliomas.Hegarty, T. J., Thornton, A. F., Diaz, R. F., Chandler, W. F., Ensminger, W. D., Junck, L., Page, M. A., Gebarski, S. S., Hood, T. W., Stetson, P. L.; Int J Radiat Oncol Biol Phys. 1990 Aug.
Management of anterior cranial base and cavernous sinus neoplasms with conservative surgery alone or in combination with fractionated photon or stereotactic proton rad...Ojemann, R. G., Thornton, A. F., Harsh, G. R.; Clin Neurosurg. 1995.
FDG hypermetabolism associated with inflammatory necrotic changes following radiation of meningioma.Fischman, A. J., Thornton, A. F., Frosch, M. P., Swearinger, B., Gonzalez, R. G., Alpert, N. M.; J Nucl Med. 1997 Jul.
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for grade III and grade IV oligoastrocytomas.Kim, L., Hochberg, F. H., Thornton, A. F., Harsh, G. R., Patel, H., Finkelstein, D., Louis, D. N.; J Neurosurg. 1996 Oct.
Spinal cord astrocytoma: response to PCV chemotherapy.Henson, J. W., Thornton, A. F., Louis, D. N.; Neurology. 2000 Jan 25.
Comparison of proton and x-ray conformal dose distributions for radiosurgery applications.Serago, C. F., Thornton, A. F., Urie, M. M., Chapman, P., Verhey, L., Rosenthal, S. J., Gall, K. P., Niemierko, A.; Med Phys. 1995 Dec.
A precision cranial immobilization system for conformal stereotactic fractionated radiation therapy.Rosenthal, S. J., Gall, K. P., Jackson, M., Thornton, A. F.; Int J Radiat Oncol Biol Phys. 1995 Dec 1.
Management of atypical and malignant meningiomas: role of high-dose, 3D-conformal radiation therapy.Hug, E. B., Devries, A., Thornton, A. F., Munzenride, J. E., Pardo, F. S., Hedley-Whyte, E. T., Bussiere, M. R., Ojemann, R.; J Neurooncol. 2000 Jun.
The clinical utility of magnetic resonance imaging in 3-dimensional treatment planning of brain neoplasms.Thornton, A. F., Sandler, H. M., Ten Haken, R. K., McShan, D. L., Fraass, B. A., La Vigne, M. L., Yanke, B. R.; Int J Radiat Oncol Biol Phys. 1992.
Results of primary and adjuvant CT-based 3-dimensional radiotherapy for malignant tumors of the paranasal sinuses.Roa, W. H., Hazuka, M. B., Sandler, H. M., Martel, M. K., Thornton, A. F., Turrisi, A. T., Urba, S., Wolf, G. T., Lichter, A. S.; Int J Radiat Oncol Biol Phys. 1994 Mar 1.
Accelerated fractionated proton/photon irradiation to 90 cobalt gray equivalent for glioblastoma multiforme: results of a phase II prospective trial.Fitzek, M. M., Thornton, A. F., Rabinov, J. D., Lev, M. H., Pardo, F. S., Munzenrider, J. E., Okunieff, P., Bussière, M., Braun, I., Hochberg, F. H., Hedley-Whyte, E. ...; J Neurosurg. 1999 Aug.
Successful treatment of esthesioneuroblastoma and neuroendocrine carcinoma with combined chemotherapy and proton radiation. Results in 9 cases.Bhattacharyya, N., Thornton, A. F., Joseph, M. P., Goodman, M. L., Amrein, P. C.; Arch Otolaryngol Head Neck Surg. 1997 Jan.
Benign meningioma: partially resected, biopsied, and recurrent intracranial tumors treated with combined proton and photon radiotherapy.Wenkel, E., Thornton, A. F., Finkelstein, D., Adams, J., Lyons, S., De La Monte, S., Ojeman, R. G., Munzenrider, J. E.; Int J Radiat Oncol Biol Phys. 2000 Dec 1.
Dose-escalation with proton/photon irradiation for Daumas-Duport lower-grade glioma: results of an institutional phase I/II trial.Fitzek, M. M., Thornton, A. F., Harsh, G., Rabinov, J. D., Munzenrider, J. E., Lev, M., Ancukiewicz, M., Bussiere, M., Hedley-Whyte, E. T., Hochberg, F. H., Pardo, F. S.; Int J Radiat Oncol Biol Phys. 2001 Sep 1.
Visual outcome of accelerated fractionated radiation for advanced sinonasal malignancies employing photons/protons.Weber, D. C., Chan, A. W., Lessell, S., McIntyre, J. F., Goldberg, S. I., Bussiere, M. R., Fitzek, M. M., Thornton, A. F., Delaney, T. F.; Radiother Oncol. 2006 Dec.

Publications par thème

 

Cerveau et SNC
AVMsMichel Schlienger et al., “Linac Radiosurgery for Cerebral Arteriovenous Malformations: Results in 169 Patients,” International Journal Radiation Oncology Biology Physics 46 (2000): 1135-1142
Lloyd Miyawaki et al., “Five Year Results of Linac Radiosurgery for Arteriovenous Malformations: Outcome for Large AVMs,” International Journal Radiation Oncology Biology Physics 44 (1999): 1089-1106
Frederik Vernimmen et al., “Stereotactic Proton Beam Therapy for Intracranial Arteriovenous Malformations,” International Journal Radiation Oncology Biology Physics 62 (2005): 44-52
RN Kjellberg et al., “Bragg-Peak Proton-Beam Therapy for Arteriovenous Malformations of the Brain,” The New England Journal of Meicine 309 (1983): 269-274
Fred Barker et al., “Dose–Volume Prediction of Radiation-related Complications After Proton Beam Radiosurgery for Cerebral Arteriovenous Malformations,” Journal Neurosurgery 99 (2003): 254-263
Long-Term Outcomes iThemba LabsFrederik Vernimmen et al., “15-Years of Proton Radiosurgery Experience at iThemba Labs, Long Term Results for AVMs, Meningiomas and Acoustic Neuromas ,” PTCOG 42 (2008): O2
MeningiomasJuergen Debus et al., “High Efficacy of Fractionated Stereotactic Radiotherapy of Large Base-of-Skull Meningiomas: Long-Term Results,” Journal of Clinical Oncology 19 (2001): 3547-3553
Georges Noel et al., “Functional Outcomes of Patients with Benign Meningiomas Treated by 3D Conformal Irradiation with a Combination of Photons and Protons,” International Journal Radiation Oncology Biology Physics 62 (2005): 1412-1422
Frederik Vernimmen et al., “Stereotactic Proton Beam Therapy of Skull Base Meningiomas,” International Journal Radiation Oncology Biology Physics 49 (2001): 99-105
Evelyn Wenkel et al., “Benign Meningioma: Partially Resected, Biopsied and Recurrent Intracranial Tumors Treated with Combined Proton and Photon Radiotherapy,” International Journal Radiation Oncology Biology Physics 48 (2000): 1363-1370
Christos Boskos et al., “Combined Proton and Photon Conformal Radiotherapy for Intracranial Atypical and Malignant Meningioma,” International Journal Radiation Oncology Biology Physics 75 (2009): 399-406
Spine SarcomasThomas DeLaney et al., “Phase II Study of High-Dose Photon/Proton Radiotherapy in the Management of Spine Sarcomas,” International Journal Radiation Oncology Biology Physics 74 (2009): 732-739
Sein
Bradley JA, Dagan R, Ho MW, Rutenberg M, Morris CG, Li Z, Mendenhall NP. Initial Report of a Prospective Dosimetric and Clinical Feasibility Trial Demonstrates the Potential of Protons to Increase the Therapeutic Ratio in Breast Cancer Compared With Photons.[Int J Radiat Oncol Biol Phys. 2016]
Bush, David A., et al. “Partial Breast Radiation Therapy With Proton Beam: 5-Year Results With Cosmetic Outcomes.” International Journal of Radiation Oncology*Biology*Physics, vol. 90, no. 3, 2014, pp. 501–505., doi:10.1016/j.ijrobp.2014.05.1308.
Bush, David A., et al. “A Technique of Partial Breast Irradiation Utilizing Proton Beam Radiotherapy: Comparison with Conformal X-Ray Therapy.” The Cancer Journal, vol. 13, no. 2, 2007, pp. 114–118., doi:10.1097/ppo.0b013e318046354b.
Brown, L. C., Mutter, R. W., & Halyard, M. Y. (2015). Benefits, risks, and safety of external beam radiation therapy for breast cancer. International Journal of Women’s Health, 7, 449–458. http://doi.org/10.2147/IJWH.S55552
Cuaron JJ, MacDonald SM, Cahlon O. Novel applications of proton therapy in breast carcinoma. Chinese clinical oncology. 2016;5(4):52. doi:10.21037/cco.2016.06.04.
Cuaron, John J. et al. Early Toxicity in Patients Treated With Postoperative Proton Therapy for Locally Advanced Breast Cancer ;
International Journal of Radiation Oncology • Biology • Physics , Volume 92 , Issue 2 , 284 - 291
Marcio Fagundes, Eugen B. Hug, Mark Pankuch, Christine Fang, Shawn McNeeley, Ling Mao, Myra Lavilla, Stacey L. Schmidt, Clark Ward, Oren Cahlon, and William F. Hartsell (2015) Proton Therapy for Local-regionally Advanced Breast Cancer Maximizes Cardiac Sparing. International Journal of Particle Therapy: Spring 2015, Vol. 1, No. 4, pp. 827-844.
Fega, R. et al. Clinical Outcomes of Breast Proton Radiation Therapy: A Multi-institutional Analysis of the Proton Collaborative Group Registry
International Journal of Radiation Oncology • Biology • Physics , Volume 99 , Issue 2 , S213 - S214
Johansson J, Isacsson U, Lindman H, Montelius A, Glimelius B. Node-positive left-sided breast cancer patients after breast-conserving surgery: potential outcomes of radiotherapy modalities and techniques. Radiother Oncol. 2002;65:89–98.
Kammerer, Emmanuel et al. Proton therapy for locally advanced breast cancer: A systematic review of the literature.
Cancer Treatment Reviews , Volume 63 , 19 – 27
Lundkvist J, Ekman M, Ericsson SR, Isacsson U, Jönsson B, Glimelius B. Economic evaluation of proton radiation therapy in the treatment of breast cancer. Radiother Oncol. 2005 May;75(2):179-85.
MacDonald SM, Patel SA, Hickey S, et al. Proton therapy for breast cancer after mastectomy: early outcomes of a prospective clinical trial. Int J Radiat Oncol Biol Phys. 2013;86:484–490.
McGee, L.A. et al. Postmastectomy Chest Wall Reirradiation With Proton Therapy for Breast Cancer
International Journal of Radiation Oncology • Biology • Physics , Volume 99 , Issue 2 , E34 - E35
Moran JM, Ben-David MA, Marsh RB, et al. Accelerated partial breast irradiation: what is dosimetric effect of advanced technology approaches? Int J Radiat Oncol Biol Phys. 2009;75:294–301.
Plastaras JP, Berman AT, Freedman GM. Special cases for proton beam radiotherapy: re-irradiation, lymphoma, and breast cancer. Semin Oncol. 2014 Dec;41(6):807-19. 
Taghian, Alphonse G., et al. “Accelerated Partial Breast Irradiation Using Proton Beams: Initial Dosimetric Experience.” International Journal of Radiation Oncology*Biology*Physics, vol. 65, no. 5, 2006, pp. 1404–1410., doi:10.1016/j.ijrobp.2006.03.017.
Taylor, Carolyn W. et al. Exposure of the Heart in Breast Cancer Radiation Therapy: A Systematic Review of Heart Doses Published During 2003 to 2013 ; International Journal of Radiation Oncology • Biology • Physics , Volume 93 , Issue 4 , 845 - 853
Cameron S. Thorpe, Joshua R. Niska, Daniel C. Brunnhoelzl, Lisa A. McGee, Christy M. Kesslering, William F. Hartsell & Carlos E. Vargas (2018) First report of proton beam therapy for breast angiosarcoma from the prospective PCG registry, Acta Oncologica, 
Francesco Tommasino, Francesco Fellin, Stefano Lorentini, Paolo Farace. Impact of dose engine algorithm in pencil beam scanning proton therapy for breast cancer
https://doi.org/10.1016/j.ejmp.2018.05.018
Xu, Natalie MD; Ho, Meng Wei MS; Li, Zuofeng DSc; Morris, Christopher G. MS; Mendenhall, Nancy P. MD. Can Proton Therapy Improve the Therapeutic Ratio in Breast Cancer Patients at Risk for Nodal Disease?
American Journal of Clinical Oncology: December 2014 - Volume 37 - Issue 6 - p 568–574
“Pragmatic Randomized Trial of Proton vs. Photon Therapy for Patients With Non-Metastatic Breast Cancer: A Radiotherapy Comparative Effectiveness (RADCOMP) Consortium Trial.” Full Text View - ClinicalTrials.gov, clinicaltrials.gov/ct2/show/NCT02603341.
Yeux
Jean-Pierre Caujolle et al., “Proton Beam Radiotherapy for Uveal Melanomas at Nice Teaching Hospital: 16 Years’ Experience,” International Journal Radiation Oncology Biology Physics (2009): 1-6
John Munzenrider, “Uveal Melanomas,” Hematology/Oncology Clinics of North America 15 (2001): 389-402
Bekkering, Geertruida E., et al. “The Effectiveness and Safety of Proton Radiation Therapy for Indications of the Eye.” Strahlentherapie Und Onkologie, vol. 185, no. 4, 2009, pp. 211–221., doi:10.1007/s00066-009-1900-4.
Char, Devron H., et al. “Laser and Proton Radiation to Reduce Uveal Melanoma–Associated Exudative Retinal Detachments.” American Journal of Ophthalmology, vol. 136, no. 1, 2003, pp. 180–182., doi:10.1016/s0002-9394(02)02292-4.
Ciulla, Thomas A, et al. “Proton Therapy for Exudative Age-Related Macular Degeneration: a Randomized, Sham-Controlled Clinical Trial.” American Journal of Ophthalmology, vol. 134, no. 6, 2002, pp. 905–906., doi:10.1016/s0002-9394(02)01821-4.
Chang JW, Yu YS, Kim JY, et al. The Clinical Outcomes of Proton Beam Radiation Therapy for Retinoblastomas That Were Resistant to Chemotherapy and Focal Treatment. Korean Journal of Ophthalmology : KJO. 2011;25(6):387-393. doi:10.3341/kjo.2011.25.6.387.
Mouw KW, Sethi RV, Yeap BY, et al. Proton Radiotherapy for the Treatment of Retinoblastoma. International journal of radiation oncology, biology, physics. 2014;90(4):863-869. doi:10.1016/j.ijrobp.2014.07.031.
Krengli, Marco et al., Proton radiation therapy for retinoblastoma: Comparison of various intraocular tumor locations and beam arrangements
International Journal of Radiation Oncology • Biology • Physics , Volume 61 , Issue 2 , 583 - 593
Tête et Cou
Clinical OutcomesJerry Slater et al., “Proton Radiation for Treatment of Cancer of the Oropharynx: Early Experience at Loma Linda University Medical Center Using a Concomitant Boost Technique,” International Journal Radiation Oncology Biology Physics 62 (2005): 494-500
A.W. Chan, “Change in Patterns of Relapse After Combined Proton and Photon Irradiation for Locally Advanced Paranasal Sinus Cancer,” International Journal Radiation Oncology Biology Physics 60 Volume 1 Supplement (2004): S320
Clinical ReviewsAnnie Chan and Norbert Liebsch, “Proton Radiation Therapy for Head and Neck,” Journal of Surgical Oncology 97 (2008): 697-700
Dosimetry SlidesUlrike Mock et al., “Treatment Planning Comparison of Conventional, 3D Conformal, Intensity Modulated Photon (IMRT) and Proton Therapy for Paranasal Sinus Carcinoma,” International Journal Radiation Oncology Biology Physics 58 (2004): 147-154
M Krengli et al., “Treatment Planning Comparison of Photon IMRT, Active and Passive Proton Therapy, and Carbon Ion Therapy for Treatment of Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics, Proceedings of the 48th Annual ASTRO Meeting (2006): S669
Marloes Steneker, Antony Lomax and Uwe Schneider, “Intensity Modulated Photon and Proton Therapy for the Treatment of Head and Neck Tumors,” Radiotherapy and Oncology 80 (2006): 263-267
Dosimetry SlidesD Yeung et al., “Dosimetric Comparison of IMRT and Proton Therapy for Head and Neck Tumors,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S412
Seminal Papers
Acceleration FractionationKaren Fu et al., “A Radiation Therapy Oncology Group Phase III Randomized Study to Compare Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinomas: First Report of RTOG 9003,” International Journal Radiation Oncology Biology Physics 48 (2000): 7-16
A Trotti et al., “Long Term Outcomes of RTOG 90–03: A Comparison of Hyperfractionation and Two Variants of Accelerated Fractionation to Standard Fractionation Radiotherapy for Head and Neck Squamous Cell Carcinoma,” International Journal Radiation Oncology Biology Physics 63 Number 2 Supplement (2005): S70
H Rodney Withers and Lester Peters, “Transmutability of Dose and Time Commentary on the First Report of RTOG 90003 (K. K. Fu et al.),” 48 (2000): 1-2
Radiation Chemotherapy TreatmentsM Al-Sarraf et al., “Chemoradiotherapy versus Radiotherapy in Patients with Advanced Nasopharyngeal Cancer: Phase III Randomized Intergroup Study 0099,” Journal of Clinical Oncology 16 (1998): 1310-1317
Arlene A. Forastiere et al., “Concurrent Chemotherapy and Radiotherapy for Organ Preservation in Advanced Laryngeal Cancer,” The New England Journal of Medicine 349 (2003): 2091-2098
Side EffectsK. S. Clifford Chao et al., “A Prospective Study of Salivary Function Sparing in Patients with Head-and-Neck Cancers Receiving Intensity-Modulated or Three-Dimensional Radiation Therapy: Initial Results,” International Journal Radiation Oncology Biology Physics 49 (2001): 907-916
Avraham Eisbruch et al., “Dose, Volume and Function Relationships in Parotid Salivary Glands Following Conformal and Intensity-Modulated Irradiation of Head and Neck Cancer,” International Journal Radiation Oncology Biology Physics 45 (1999): 577–587
Avraham Eisbruch et al., “Xerostomia and Its Predictors Following Parotid-Sparing Irradiation of Head-and-Neck Cancer,” International Journal Radiation Oncology Biology Physics 50 (2001): 695-704
Poumons
Clinical StudiesDavid Bush et al., “Proton-Beam Radiotherapy for Early-Stage Lung Cancer,” Chest 116 (1999): 1313-1319
David Bush et al., “Hypofractionated Proton Beam Radiotherapy for Stage I Lung Cancer,” Chest 126 (2004): 1198-1203
Keiji Nihei et al., “High-Dose Proton Beam Therapy for Stage I Non-Small-Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 65 (2006): 107–111
Reiner Bonnet et al., “Effects of Proton and Combined Proton/Photon Beam Radiation on Pulmonary Function in Patients with Resectable but Medically Inoperable Non-Small Cell Lung Cancer,” Chest 120 (2001): 1803-1810
Masaharu Hata et al., “Hypofractionated High-Dose Proton Beam Therapy for Stage I Non-Small-Cell Lung Cancer: Preliminary Results of a Phase I/II Clinical Study,” International Journal Radiation Oncology Biology Physics 68 (2007): 786-793
Foote, Robert L, et al. “The clinical case for proton beam therapy”, Radiation Oncology (London, England), BioMed Central, 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3549771/.
Side EffectsSamir Sejpal et al., “Does Proton Beam Radiotherapy Reduce Treatment Related Pneumonitis Compared to IMRT in Patients with Locally Advanced Non-Small-Cell Lung Cancer Treated with Concurrent Chemotherapy?” PTCOG 47 (2008): O17
Ritsuko Komaki et al., “Reduction of Bone Marrow Suppression for Patients with Stage III NSCLC Treated by Proton and Chemotherapy Compared with IMRT and Chemotherapy” PTCOG 47 (2008): O10
Mary Graham et al., “Clinical Dose-Volume Histogram Analysis for Pneumonitis after 3D Treatment for Non-Small Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 45 (1999): 323–329
Aaron Allen et al., “Fatal Pneumonitis Associated with Intensity-Modulated Radiation Therapy for Mesothelioma,” International Journal Radiation Oncology Biology Physics 64 (2006): 640–645
Ellen Yorke et al., “Correlation of Dosimetric Factors and Radiation Pneumonitis for Non-Small-Cell Lung Cancer Patients in a Recently Completed Dose Escalation Study,” International Journal Radiation Oncology Biology Physics 63 (2005): 672–682
Yvette Seppenwoolde et al., “Comparing Different NTCP Models that Predict the Incidence of Radiation Pneumonitis,” ,” International Journal Radiation Oncology Biology Physics 55 (2003): 724-735
Chang, Joe Y. “Proton Beam Radiotherapy and Chemotherapy for Non–Small Cell Lung Cancer.” JAMA Internal Medicine, American Medical Association, 10 Aug. 2017, jamanetwork.com/journals/jamaoncology/article-abstract/2644653?redirect=true.
Treatment Planning StudiesJoe Chang et al., “Significant Reduction of Normal Tissue Dose by Proton Radiotherapy Compared with Three-Dimensional Conformal or Intensity-Modulated Radiation Therapy in Stage I or Stage III Non-Small-Cell Lung Cancer,” International Journal Radiation Oncology Biology Physics 65 (2006): 1087-1096
Xiaodong Zhang et al., “Intensity-Modulated Proton Therapy Reduces the Dose to Normal Tissue Compared with Intensity-Modulated Radiation Therapy or Passive Scanning Proton Therapy and Enables Individualized Radical Radiotherapy for Extensive Stage IIIB Non-Small-Cell Lung Cancer: A Virtual Clinical Study,” International Journal Radiation Oncology Biology Physics (2009): 1-10
Pédiatriques
Clinical OutcomesTorunn Yock et al., “Proton Radiotherapy for Orbital Rhabdomyosarcoma: Clinical Outcome and a Dosimetric Comparison with Photons,” International Journal Radiation Oncology Biology Physics 63 (2005): 1161–1168
T.I. Yock et al., “Proton Radiotherapy for Ependymoma: Initial Clinical Outcomes and Dose Comparisons for Intensity Modulated Radiation With Photons, Proton Radiation, and Intensity Modulated Proton Therapy,” International Journal Radiation Oncology Biology Physics, Proceedings of the 49th Annual ASTRO Meeting (2007): S575
Eugen Hug et al., “Conformal Proton Radiation Therapy for Pediatric Low-Grade Astrocytomas,” Strahlentherapie und Onkologie 178 (2002):10–17
Grace E. Yuh et al., “Reducing Toxicity from Craniospinal Irradiation: Using Proton Beams to Treat Medulloblastoma in Young Children,” The Cancer Journal 10 (2004): 386-390
Quoc T. Luu et al., “Fractionated Proton Radiation Treatment for Pediatric Craniopharyngioma: Preliminary Report,” The Cancer Journal 12 (2006): 155-159
Jean-Louis Habrand, “Proton Therapy in Pediatric Skull Base and Cervical Canal Low-Grade Bone Malignancies,” International Journal Radiation Oncology Biology Physics 71 (2008): 672-675
Shannon MacDonald et al., “Proton Radiotherapy for Childhood Ependymoma: Initial Clinical Outcomes and Dose Comparisons,” International Journal Radiation Oncology Biology Physics 71 (2008): 979–986
Hans Peter Rutz et al., “Postoperative Spot-Scanning Proton Radiation Therapy for Chordoma and Chondrosarcoma in Children and Adolescents: Initial Experience at Paul Scherrer Institute,” International Journal Radiation Oncology Biology Physics 71 (2008): 220-225
S. MacDonald et al., “Proton Radiotherapy for Pediatric Central Nervous System Germ Cell Tumors: Early Clinical Outcomes,” International Journal Radiation Oncology Biology Physics, Proceedings of the 51st Annual ASTRO Meeting (2009): S509
Armstrong, F. Daniel. “Proton-Beam Radiation Therapy and Health-Related Quality of Life in Children With CNS Tumors.” Journal of Clinical Oncology, vol. 30, no. 17, Oct. 2012, pp. 2028–2029., doi:10.1200/jco.2012.42.1248.
Cotter, Shane E., et al. “Proton Radiotherapy for Solid Tumors of Childhood.” Technology in Cancer Research & Treatment, vol. 11, no. 3, 2012, pp. 267–278., doi:10.7785/tcrt.2012.500295.
Habrand, Jean-Louis, et al. “Proton Therapy in Pediatric Skull Base and Cervical Canal Low-Grade Bone Malignancies.” International Journal of Radiation https://doi.org/10.1016/j.ijrobp.2008.02.043
Buehrer, S., et al. “Evaluation of Propofol for Repeated Prolonged Deep Sedation in Children Undergoing Proton Radiation Therapy.” British Journal of Anaesthesia, vol. 99, no. 4, 2007, pp. 556–560., doi:10.1093/bja/aem207.
Radiographic Evidence of the Distal EdgeStephanie Krejcarek et al., “Physiologic and Radiographic Evidence of the Distal Edge of the Proton Beam in Craniospinal Irradiation,” International Journal Radiation Oncology Biology Physics 68 (2007): 646-649
Secondary Malignancies
Raymond Miralbell, Anthony Lomax, Laura Cella and Uwe Schneider, “Potential Reduction of the Incidence of Radiation-Induced Second Cancers by Using Proton Beams in the Treatment of Pediatric Tumors,” International Journal Radiation Oncology Biology Physics 54 (2002): 824-829
Seminal Papers in Pediatric Cancer Treatment
Ching-Hon Pui et al., “Extended Follow-up of Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia,” The New England Journal of Medicine 349 (2003):640-649
Side Effects – Cost Effectiveness
Jonas Lundkvist et al., “Cost-Effectiveness of Proton Radiation in the Treatment of Childhood Medulloblastoma,” Cancer 103 (2005): 793-801
Side Effects – Effects on IQ
Thomas Merchant et al., “Proton Versus Photon Radiotherapy for Common Pediatric Brain Tumors: Comparison of Models of Dose Characteristics and Their Relationship to Cognitive Function,” Pediatric Blood Cancer 51 (2008): 110–117
Thomas Merchant et al., “Modeling Radiation Dosimetry to Predict Cognitive Outcomes in Pediatric Patients with CNS Embryonal Tumors Including Medulloblastoma,” International Journal Radiation Oncology Biology Physics 65 (2006): 210–221
Thomas Merchant et al., “Radiation Dosimetry Predicts IQ After Conformal Radiation Therapy in Pediatric Patients with Localized Ependymoma,” International Journal Radiation Oncology Biology Physics 63 (2005): 1546-1554
M Douglas Ris et al., “Intellectual Outcome After Reduced-Dose Radiation Therapy Plus Adjuvant Chemotherapy for Medulloblastoma: A Children’s Cancer Group Study,” Journal of Clinical Oncology 19 (2001): 3470-3476
Side Effects – Growth Hormone
Thomas Merchant et al., “Radiation Dose-Volume Effects on Growth Hormone Secretion,” International Journal Radiation Oncology Biology Physics 52 (2002): 1264-1270
James Gurney et al., “Endocrine and Cardiovascular Late Effects Among Adult Survivors of Childhood Brain Tumors,” Cancer 97 (2003): 663-673
Side Effects – Ototoxicity (hearing)
Y Chen et al., “Improved Hearing Outcomes From Cochlear Dose Reduction Using Proton Posterior Fossa Boost in Pediatric Medulloblastoma,” International Journal Radiation Oncology Biology Physics, Proceedings of the 49th Annual ASTRO Meeting (2007): S579
Eugene Huang et al., “Intensity-Modulated Radiation Therapy for Pediatric Medulloblastoma: Early Report on the Reduction of Ototoxicity,” International Journal Radiation Oncology Biology Physics 52 (2002): 599-605
Side Effects – Secondary Malignancies

Raymond Miralbell et al., “Potential Reduction of the Incidence of Radiation-Induced Second Cancers by Using Proton Beams in the Treatment of Pediatric Tumors,” International Journal Radiation Oncology Biology Physics 54 (2002): 824-829
Side Effects – Thyroid Dysfunction

Umberto Ricardi et al., “Thyroid Dysfunction as a Late Effect in Childhood Medulloblastoma: A comparison of Hyperfractionated versus Conventionally Fractionated Craniospinal Radiotherapy,” International Journal Radiation Oncology Biology Physics 50 (2001): 1287-1294
Treatment Planning

W.H. Clair et al., “Advantage of Protons Compared to Conventional X-ray or IMRT in the Treatment of a Pediatric Patient with Medulloblastoma,” International Journal Radiation Oncology Biology Physics 58 (2004): 727-734
Catherine Lee et al., “Treatment Planning with Protons for Pediatric Retinoblastoma, Medulloblastoma, and Pelvic Sarcoma: How Do Protons Compare with Other Conformal Techniques?” International Journal Radiation Oncology Biology Physics 63 (2005): 362-372
Marco Krengli et al., “Proton Radiation Therapy for Retinoblastoma: Comparison of Various Intraocular Tumor Locations and Beam Arrangements,” International Journal Radiation Oncology Biology Physics 61 (2005): 583-593
Prostate
Dose Escalation TrialsDeborah Kuban et al., “Long-Term Results of the M.D. Anderson Randomized Dose-Escalation Trial for Prostate Cancer,” International Journal Radiation Oncology Biology Physics 70 (2008): 67-74
Stephanie Peeters et al., “Dose-Response in Radiotherapy for Localized Prostate Cancer: Results of the Dutch Multicenter Randomized Phase III Trial Comparing 68 Gy of Radiotherapy With 78 Gy,” Journal of Clinical Oncology 24 (2008): 1990-1996
David P Dearnaley et al., “Escalated-Dose versus Standard-Dose Conformal Radiotherapy in Prostate Cancer: First Results from the MRC RT01 Randomised Controlled Trial,” Lancet Oncology 8 (2007): 475-487
Anthony Zietman et al., “CORRECTION: Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial,” Journal of American Medicine Association 299 (2008): 899-900
Anthony Zietman et al., “Comparison of Conventional-Dose vs High-Dose Conformal Radiation Therapy in Clinically Localized Adenocarcinoma of the Prostate: A Randomized Controlled Trial,” Journal of American Medicine Association 294 (2005): 1233-1239
A.L. Zietman et al., “A Phase III Trial Employing Conformal Photons with Proton Boost in Early-Stage Prostate Cancer: Conventional Dose (70.2 GyE) Compared to High-Dose Irradiation (79.2 GyE): Long-Term Updated Analysis of Proton Radiation Oncology Group (PROG)/American College of Radiology (ACR) 95–09,” International Journal Radiation Oncology Biology Physics, Proceedings of the 51st Annual ASTRO Meeting (2009): S11
Gustavo Arruda Viani, “Higher-Than-Conventional Doses in Localized Prostate Cancer Treatment: A Meta-Analysis of Randomized, Controlled Trials,” International Journal Radiation Oncology Biology Physics 74 (2009): 1405–1418
Loma Linda ExperienceJerry Slater et al., “Proton Therapy for Prostate Cancer: the Initial Loma Linda University Experience,” International Journal Radiation Oncology Biology Physics 59 (2004): 348-352
Jerry Slater et al., “Conformal Proton Therapy for Prostate Carcinoma,” International Journal Radiation Oncology Biology Physics 42 (1998): 299–304
Quality of Life
J.A. Talcott et al., “Long-Term Quality of Life After Conventional-Dose versus High-Dose Radiation for Prostate Cancer: Results from a Randomized Trial (PROG 95–09),” Journal of Clinical Oncology, 2008 ASCO Annual Meeting Proceedings (Post-Meeting Edition) 26 (2008): 15S
Hoppe, Bradford S., et al. “Erectile Function, Incontinence, and Other Quality of Life Outcomes Following Proton Therapy for Prostate Cancer in Men 60 Years Old and Younger.” Cancer, vol. 118, no. 18, 2012, pp. 4619–4626., doi:10.1002/cncr.27398.
Talcott, James A. “Patient-Reported Long-Term Outcomes After Conventional and High-Dose Combined Proton and Photon Radiation for Early Prostate Cancer.” Jama, vol. 303, no. 11, 2010, p. 1046., doi:10.1001/jama.2010.287.
Toxicity
Carlos Vargas et al., “Dose-Volume Comparison of Proton Therapy and Intensity-Modulated Radiotherapy for Prostate Cancer,” International Journal Radiation Oncology Biology Physics 70 (2008): 744–751
Mark Storey et al., “Complications from Radiotherapy Dose Escalation in Prostate Cancer: Preliminary Results of a Randomized Trail,” International Journal Radiation Oncology Biology Physics 48 (2000): 635–642
Susan Tucker et al., “Comparison of Rectal Dose-Wall Histogram versus Dose-Volume Histogram for Modeling the Incidence of Late Rectal Bleeding after Radiotherapy,” International Journal Radiation Oncology Biology Physics 60 (2004): 1589–1601
Mendenhall, Nancy P., et al. “Early Outcomes From Three Prospective Trials of Image-Guided Proton Therapy for Prostate Cancer.” International Journal of Radiation Oncology*Biology*Physics, vol. 82, no. 1, 2012, pp. 213–221., doi:10.1016/j.ijrobp.2010.09.024.
Nihei, Keiji, et al. “Multi-Institutional Phase II Study of Proton Beam Therapy for Organ-Confined Prostate Cancer Focusing on the Incidence of Late Rectal Toxicities.” International Journal of Radiation Oncology*Biology*Physics, vol. 81, no. 2, 2011, pp. 390–396., doi:10.1016/j.ijrobp.2010.05.027.
Curtiland Deville Jr, Akansha Jain, Wei-Ting Hwang, Kristina D. Woodhouse, Stefan Both, Shiyu Wang, Peter E. Gabriel, John P. Christodouleas, Justin Bekelman, Zelig Tochner & Neha Vapiwala (2018) Initial report of the genitourinary and gastrointestinal toxicity of post-prostatectomy proton therapy for prostate cancer patients undergoing adjuvant or salvage radiotherapy, Acta Oncologica, DOI: 10.1080/0284186X.2018.1487583
Treatment Planning
Laura Cella, Anthony Lomax and Raymond Miralbell, “Potential Role of Intensity Modulated Proton Beams in Prostate Cancer Radiotherapy,” International Journal Radiation Oncology Biology Physics 49 (2001): 217–223
Bhishamjit Chera et al., “Dosimetric Study of Pelvic Proton Radiotherapy for High-Risk Prostate Cancer,” International Journal Radiation Oncology Biology Physics 75 (2009): 994–1002
Hoppe, B.s., et al. “Comparative Effectiveness Study of Proton Therapy Versus IMRT for Definitive Treatment of Prostate Cancer Based on Patient-Reported Outcomes.” International Journal of Radiation Oncology*Biology*Physics, vol. 87, no. 2, 2013, doi:10.1016/j.ijrobp.2013.06.909.
Tumeurs secondaires
C.S. Chung et al., “Comparative Analysis of Second Malignancy Risk in Patients Treated with Proton Therapy versus Conventional Photon Therapy,” International Journal Radiation Oncology Biology Physics 72 Number 1 Supplement (2008): S8
S.L. Liauw et al.,” Second Malignancies After Prostate Brachytherapy: Incidence of Bladder and Colorectal Cancers in Patients With 15 Years of Potential Follow-up,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S390
L.A. McGee et al.,” Comparison of Second Cancer Risk in Prostate Cancer Patients Treated With Neutron/Photon Irradiation, Photon Irradiation, or Prostatectomy,” International Journal Radiation Oncology Biology Physics 66 Number 3 Supplement (2006): S318
Eric Hall, “Intensity-Modulated Radiation Therapy, Protons and the Risk of Second Cancers,” International Journal Radiation Oncology Biology Physics 65 (2006): 1-7
Bernard Gottschalk, “Neutron Dose in Scattered and Scanned Proton Beams: In Regard to Eric J. Hall (Int J Radiat Oncol Biol Phys 2006;65:1–7),” International Journal Radiation Oncology Biology Physics 66 (2006): 1594
Wayne Newhauser et al.,” The Risk of Developing a Second Cancer After Receiving Craniospinal Proton Irradiation,” Physics in Medicine and Biology 54 (2009): 2277-2291
Jonas Fontenot, “Risk of Secondary Malignant Neoplasms from Proton Therapy and Intensity-Modulated X-Ray Therapy for Early-Stage Prostate Cancer,” International Journal Radiation Oncology Biology Physics 74 (2009): 616-622
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